Article
An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome.
Nucleus (Austin, Tex.) - 1 Jan 2018
Harhouri Karim, Frankel Diane, Bartoli Catherine, Roll Patrice, De Sandre-Giovannoli Annachiara, Lévy Nicolas
Abstract excerpt
Hutchinson-Gilford progeria syndrome (HGPS) is a sporadic, autosomal dominant disorder characterized by premature and accelerated aging symptoms leading to death at the mean age of 14.6 years usually due to cardiovascular complications. HGPS is caused by a de novo point mutation in the LMNA gene encoding the intermediate filament proteins lamins A and C which are structural components of the nuclear lamina. This...
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