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Article

Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes.

Oncotarget - 24 May 2016

Kreienkamp Ray, Croke Monica, Neumann Martin A, Bedia-Diaz Gonzalo, Graziano Simona, Dusso Adriana, Dorsett Dale, Carlberg Carsten, Gonzalo Susana

Abstract excerpt

Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating incurable premature aging disease caused by accumulation of progerin, a toxic lamin A mutant protein. HGPS patient-derived cells exhibit nuclear morphological abnormalities, altered signaling pathways, genomic instability, and premature senescence. Here we uncover new molecular mechanisms contributing to cellular decline in progeria. We demonstrate that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27145372
DOI: 10.18632/oncotarget.9065
PMCID: PMC5058660

Genes

VDR
BRCA1
LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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