Article
Hepatitis B Virus--Specific and Global T-Cell Dysfunction in Chronic Hepatitis B.
Gastroenterology - 1 Mar 2016
Park Jang-June, Wong David K, Wahed Abdus S, Lee William M, Feld Jordan J, Terrault Norah, Khalili Mandana, Sterling Richard K, Kowdley Kris V, Bzowej Natalie, Lau Daryl T, Kim W Ray, Smith Coleman, Carithers Robert L, Torrey Keith W, Keith James W, Levine Danielle L, Traum Daniel, Ho Suzanne, Valiga Mary E, Johnson Geoffrey S, Doo Edward, Lok Anna S F, Chang Kyong-Mi
Abstract excerpt
BACKGROUND & AIMS: T cells play a critical role in viral infection. We examined whether T-cell effector and regulatory responses can define clinical stages of chronic hepatitis B (CHB). METHODS: We enrolled 200 adults with CHB who participated in the National Institutes of Health-supported Hepatitis B Research Network from 2011 through 2013 and 20 uninfected individuals (controls). Peripheral blood lymphocytes...
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