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Article

Common Variant in PLD3 Influencing Cerebrospinal Fluid Total Tau Levels and Hippocampal Volumes in Mild Cognitive Impairment Patients from the ADNI Cohort.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Tan Meng-Shan, Wang Ping, Ma Fang-Chen, Li Jie-Qiong, Tan Chen-Chen, Yu Jin-Tai, Tan Lan

Abstract excerpt

Recent studies found the variants in Alzheimer's disease (AD) risk gene PLD3 were associated with cognitive function, but its detailed mechanism before typical AD onset was unknown. Our current study examined the impact of PLD3 common variant rs11667768 on cerebrospinal fluid (CSF) total-tau and phosphorylated-tau levels and structural MRI from the ADNI database. We found rs11667768 was significantly associated...

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PMID: 30103332
DOI: 10.3233/JAD-180431

Genes

PLD3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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