Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.

BMC medical genetics - 12 Sept 2018

Sode Jacob, Bank Steffen, Vogel Ulla, Andersen Paal Skytt, Sørensen Signe Bek, Bojesen Anders Bo, Andersen Malene Rohr, Brandslund Ivan, Dessau Ram Benny, Hoffmann Hans Jürgen, Glintborg Bente, Hetland Merete Lund, Locht Henning, Heegaard Niels Henrik, Andersen Vibeke

Abstract excerpt

BACKGROUND: Ankylosing spondylitis (AS) results from the combined effects of susceptibility genes and environmental factors. Polymorphisms in genes regulating inflammation may explain part of the heritability of AS. METHODS: Using a candidate gene approach in this case-control study, 51 mainly functional single nucleotide polymorphisms (SNPs) in genes regulating inflammation were assessed in 709 patients with AS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interleukin-17
Share to Interleukin-23

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Share to Receptors, Interleukin

Share to Receptors, Tumor Necrosis Factor, Type I

Share to Spondylitis, Ankylosing

Share to Toll-Like Receptor 1

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 30208882
DOI: 10.1186/s12881-018-0680-z
PMCID: PMC6136164

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis.PMID 30208882Read ↗

Associations of Tumor Necrosis Factor Alpha Gene Polymorphisms and Ankylosing Spondylitis Susceptibility: A Meta-analysis Based on 35 Case-control Studies.Semantic proximity Read ↗

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.Semantic proximity Read ↗

Genetics and the pathogenesis of ankylosing spondylitis.Semantic proximity Read ↗

Genetics of ankylosing spondylitis.Semantic proximity Read ↗

Genetics of ankylosing spondylitis and rheumatoid arthritis: where are we at currently, and how do they compare?Semantic proximity Read ↗

The genetic basis of ankylosing spondylitis: new insights into disease pathogenesisSemantic proximity Read ↗

Ankylosing spondylitis: beyond genome-wide association studies.Semantic proximity Read ↗

Influence of TNF and IL17 Gene Polymorphisms on the Spondyloarthritis Immunopathogenesis, Regardless of HLA-B27, in a Brazilian Population.Semantic proximity Read ↗

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis.Semantic proximity Read ↗

Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.Semantic proximity Read ↗

Brief report: the IL23R nonsynonymous polymorphism rs11209026 is associated with radiographic sacroiliitis in spondyloarthritis.Semantic proximity Read ↗

Allele frequency spectrum of known ankylosing spondylitis associated variants in a Swedish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.