Article
Genetics of ankylosing spondylitis and rheumatoid arthritis: where are we at currently, and how do they compare?
Clinical and experimental rheumatology - 1 Jan 2000
Maksymowych W P, Brown M A
Abstract excerpt
Both ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are common, highly heritable conditions, the pathogenesis of which are incompletely understood. Gene-mapping studies in both conditions have over the last couple of years made major breakthroughs in identifying the mechanisms by which these diseases occur. Considering RA, there is an over-representation of genes involved in TNF signalling and the...
Topics
- Arthritis, Rheumatoid
- Epitopes
- Genetic Predisposition to Disease
- Humans
- Interleukin-12
- Interleukin-23
- Major Histocompatibility Complex
- NF-kappa B
- Signal Transduction
- Spondylitis, Ankylosing
- Tumor Necrosis Factor-alpha