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Article

A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis.

PloS one - 1 Jan 2016

Vidal-Castiñeira Jose Ramón, López-Vázquez Antonio, Diaz-Peña Roberto, Diaz-Bulnes Paula, Martinez-Camblor Pablo, Coto Eliecer, Coto-Segura Pablo, Bruges-Armas Jacome, Pinto Jose Antonio, Blanco Francisco Jose, Sánchez Alejandra, Mulero Juan, Queiro Ruben, Lopez-Larrea Carlos

Abstract excerpt

The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the severity of their clinical parameters. We identified 27 variants in exons and regulatory regions. The contribution of candidate variants found to AS severity was validated by genotyping two Spanish cohorts...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Promoter Regions, Genetic

Share to Receptors, Interleukin-17

Share to Sequence Analysis, DNA

Share to Severity of Illness Index

Share to Spondylitis, Ankylosing

Source

Open in PubMed Open full text

Identifiers

PMID: 27415816
DOI: 10.1371/journal.pone.0158905
PMCID: PMC4945092

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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