Article
Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.
Blood - 27 Jun 2013
Wang Jinyong, Kong Guangyao, Liu Yangang, Du Juan, Chang Yuan-I, Tey Sin Ruow, Zhang Xinmin, Ranheim Erik A, Saba-El-Leil Marc K, Meloche Sylvain, Damnernsawad Alisa, Zhang Jingfang, Zhang Jing
Abstract excerpt
Oncogenic NRAS mutations are frequently identified in human myeloid leukemias. In mice, expression of endogenous oncogenic Nras (Nras(G12D/+)) in hematopoietic cells leads to expansion of myeloid progenitors, increased long-term reconstitution of bone marrow cells, and a chronic myeloproliferative neoplasm (MPN). However, acute expression of Nras(G12D/+) in a pure C57BL/6 background does not induce hyperactivated...
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