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Article

The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML.

Blood - 27 Jul 2023

Shao Xuejing, Xu Aixiao, Du Wenxin, Xu Tong, Huang Yunpeng, Xia Zhimei, Wang Wei, Cai Minyi, Zhang Xingya, Zhang Jianhua, Cao Ji, Xu Xiaojun, Yang Bo, He Qiaojun, Ying Meidan

Abstract excerpt

Acute myeloid leukemia (AML) is an aggressive hematological malignancy. Nearly 50% of patients who receive the most intensive treatment inevitably experience disease relapse, likely resulting from the persistence of drug-resistant leukemia stem cells (LSCs). AML cells, especially LSCs, are highly dependent on mitochondrial oxidative phosphorylation (OXPHOS) for survival, but the mechanism involved in OXPHOS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37216691
DOI: 10.1182/blood.2022019056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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