Article
Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents.
Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010
Dail Monique, Li Qing, McDaniel Andrew, Wong Jason, Akagi Keiko, Huang Ben, Kang Hio Chung, Kogan Scott C, Shokat Kevan, Wolff Linda, Braun Benjamin S, Shannon Kevin
Abstract excerpt
Mice that accurately model the genetic diversity found in human cancer are valuable tools for interrogating disease mechanisms and investigating novel therapeutic strategies. We performed insertional mutagenesis with the MOL4070LTR retrovirus in Mx1-Cre, Kras(G12D) mice and generated a large cohort of T lineage acute lymphoblastic leukemias (T-ALLs). Molecular analysis infers that retroviral integration within...
Topics
- Amino Acid Substitution
- Amyloid Precursor Protein Secretases
- Animals
- Antineoplastic Agents
- Benzamides
- Cell Line, Tumor
- Cell Lineage
- Clone Cells
- Diphenylamine