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Article

Mutation Screening of the Krüppel-like Factor 1 Gene in Individuals With Increased Fetal Hemoglobin Referred for Hemoglobinopathy Investigation in South of Iran.

Journal of pediatric hematology/oncology - 1 Apr 2018

Hamid Mohammad, Ershadi Oskouei Sanaz, Shariati Gholamreza, Babaei Esmaeil, Galehdari Hamid, Saberi Alihossein, Sedaghat Alireza

Abstract excerpt

BACKGROUND: Any mutation in the Krüppel-like factor 1 (KLF1) gene may interfere with its proper related function in the erythropoiesis process and lead to alterations in proper activation of its downstream protein through globin switching, which results in an increase in fetal hemoglobin (HbF). This study aimed to investigate whether KLF1 mutation can associate with high level of HbF in individuals with increased...

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Source

Identifiers

PMID: 29420372
DOI: 10.1097/MPH.0000000000001093

Genes

KLF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation Screening of the Krüppel-like Factor 1 Gene in Individuals With Increased Fetal Hemoglobin Referred for Hemoglobinopathy Investigation in South of Iran.PMID 29420372Read ↗

KLF1 gene mutations in Chinese adults with increased fetal hemoglobin.Semantic proximity Read ↗

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Mutation screening of the Krüppel-like factor 1 gene using single-strand conformational polymorphism in a cohort of Iranian β-thalassemia patients.Semantic proximity Read ↗

Changes in hematological parameters in α-thalassemia individuals co-inherited with erythroid Krüppel-like factor mutations.Semantic proximity Read ↗

Krüppel-Like Factor 1: A Pivotal Gene Regulator in ErythropoiesisSemantic proximity Read ↗

KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia.Semantic proximity Read ↗

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Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.Semantic proximity Read ↗

Alterations on high HbF levels may be associated with KLF1 gene mutations.Semantic proximity Read ↗

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