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Article

Krüppel-like factor 1: hematologic phenotypes associated with KLF1 gene mutations.

International journal of laboratory hematology - 1 May 2015

Waye J S, Eng B

Abstract excerpt

Krüppel-like factor 1 (KLF1) is a pleiotropic erythroid transcription factor that is essential for hematopoiesis. KLF1 mutations have been associated with severe hematologic disorders, including congenital dyserythropoietic anemia type IV (CDAN4) due to a dominant-negative missense mutation (c.973G>A, p.Glu325Lys) and transfusion-dependent hemolytic anemia in compound heterozygotes for loss-of-function mutations....

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Share to Anemia, Hemolytic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25976964
DOI: 10.1111/ijlh.12356

Genes

KLF1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Krüppel-like factor 1: hematologic phenotypes associated with KLF1 gene mutations.PMID 25976964Read ↗

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