Article
Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles.
Journal of molecular and cellular cardiology - 1 Oct 2018
Li Gang, Khandekar Aditi, Yin Tiankai, Hicks Stephanie C, Guo Qiusha, Takahashi Kentaro, Lipovsky Catherine E, Brumback Brittany D, Rao Praveen K, Weinheimer Carla J, Rentschler Stacey L
Abstract excerpt
Several inherited arrhythmias, including Brugada syndrome and arrhythmogenic cardiomyopathy, primarily affect the right ventricle and can lead to sudden cardiac death. Among many differences, right and left ventricular cardiomyocytes derive from distinct progenitors, prompting us to investigate how embryonic programming may contribute to chamber-specific conduction and arrhythmia susceptibility. Here, we show...
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