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Article

Canonical Wnt Signaling Regulates Atrioventricular Junction Programming and Electrophysiological Properties

7 Nov 2014

Abstract excerpt

RATIONALE: Proper patterning of the atrioventricular canal (AVC) is essential for delay of electrical impulses between atria and ventricles, and defects in AVC maturation can result in congenital heart disease. OBJECTIVE: To determine the role of canonical Wnt signaling in the myocardium during AVC development. METHODS AND RESULTS: We used a novel allele of β-catenin that preserves β-catenin's cell adhesive...

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Share to Cardiac Arrhythmias and Treatments
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PMID: 25599332
DOI: 10.1161/circresaha.116.304731

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