Article

WNT inhibition primes the transcriptional landscape of mesoderm to initiate a phased ventricular cardiomyocyte specification programme

2025-11-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Aims</h4> Cardiac reprogramming holds promise for treating ischemic heart diseases and advancing personalised medicine, but current approaches do not yet reliably generate human functional, homogeneous cardiomyocyte cultures. This limited success likely reflects our incomplete understanding of hierarchical transcriptional programmes guiding cardiomyocyte specification. Here,...

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Literature Corpus work: f2aa24dc-97fe-565a-ae94-18937610b369
DOI: 10.1101/2025.11.11.687613

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