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Brd4-bound enhancers drive cell-intrinsic sex differences in glioblastoma

13 Apr 2021

Abstract excerpt

Sex can be an important determinant of cancer phenotype, and exploring sex-biased tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established isogenic murine model of glioblastoma (GBM), we discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and...

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PMID: 33850013
DOI: 10.1073/pnas.2017148118

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