Article
Sex- and mutation-specific p53 gain-of-function activity in gliomagenesis.
Cancer research communications - 1 Dec 2021
Rockwell Nathan C, Yang Wei, Warrington Nicole M, Staller Max V, Griffith Malachi, Griffith Obi L, Gurnett Christina A, Cohen Barak A, Baldridge Dustin, Rubin Joshua B
Abstract excerpt
In cancer, missense mutations in the DNA-binding domain of TP53 are common. They abrogate canonical p53 activity and frequently confer gain-of-oncogenic function (GOF) through localization of transcriptionally active mutant p53 to non-canonical genes. We found that several recurring p53 mutations exhibit a sex difference in frequency in patients with glioblastoma (GBM). In vitro and in vivo analysis of three...
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