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CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma

14 Mar 2019

Abstract excerpt

Glioblastoma (GBM) is a lethal brain tumour. Despite therapy with surgery, radiation, and alkylating chemotherapy, most people have recurrence within 6 months and die within 2 years. A major reason for recurrence is resistance to DNA damage. Here, we demonstrate that CHD4, an ATPase and member of the nucleosome remodelling and deactetylase (NuRD) complex, drives a component of this resistance. CHD4 is...

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PMID: 30872624
DOI: 10.1038/s41598-019-40327-w

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