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Brd4-bound enhancers drive cell intrinsic sex differences in glioblastoma

2017-10-05

Abstract excerpt

Sex can be an important determinant of cancer phenotype, and exploring sex-biased tumor biology holds promise for identifying novel therapeutic targets and new approaches to cancer treatment. In an established isogenic murine model of glioblastoma, we discovered correlated transcriptome-wide sex differences in gene expression, H3K27ac marks, large Brd4-bound enhancer usage, and Brd4 localization to Myc and p53 gen...

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Literature Corpus work
39133ff7-d462-58ea-9c44-a13a369f8305
DOI
10.1101/199059
Open publication

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