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Article

Dimerization is essential for 14-3-3zeta stability and function in vivo.

The Journal of biological chemistry - 15 Jan 2010

Messaritou Georgia, Grammenoudi Sofia, Skoulakis Efthimios M C

Abstract excerpt

Members of the conserved 14-3-3 protein family spontaneously self-assemble as homo- and heterodimers via conserved sequences in the first four (alphaA-alphaD) of the nine helices that comprise them. Dimeric 14-3-3s bind conserved motifs in diverse protein targets involved in multiple essential cellular processes including signaling, intracellular trafficking, cell cycle regulation, and modulation of enzymatic...

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Identifiers

PMID: 19920133
DOI: 10.1074/jbc.M109.045989
PMCID: PMC2804327

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Source receipt: pubmed, retrieved 7 Sept 2026.

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