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Article

Dimerization is essential for 14-3-3zeta stability and function in vivo.

The Journal of biological chemistry - 15 Jan 2010

Messaritou Georgia, Grammenoudi Sofia, Skoulakis Efthimios M C

Abstract excerpt

Members of the conserved 14-3-3 protein family spontaneously self-assemble as homo- and heterodimers via conserved sequences in the first four (alphaA-alphaD) of the nine helices that comprise them. Dimeric 14-3-3s bind conserved motifs in diverse protein targets involved in multiple essential ce...

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Identifiers

PMID: 19920133
DOI: 10.1074/jbc.M109.045989
PMCID: PMC2804327

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19920133-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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