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Article

Conditional disruption of interactions between Gαi2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury.

BMC pharmacology & toxicology - 5 Jun 2014

Parra Sergio, Huang Xinyan, Charbeneau Raelene A, Wade Susan M, Kaur Kuljeet, Rorabaugh Boyd R, Neubig Richard R

Abstract excerpt

BACKGROUND: Regulator of G protein signaling (RGS) proteins suppress G protein coupled receptor signaling by catalyzing the hydrolysis of Gα-bound guanine nucleotide triphosphate. Transgenic mice in which RGS-mediated regulation of Gαi2 is lost (RGS insensitive Gαi2G184S) exhibit beneficial (protection against ischemic injury) and detrimental (enhanced fibrosis) cardiac phenotypes. This mouse model has revealed...

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Identifiers

PMID: 24899231
DOI: 10.1186/2050-6511-15-29
PMCID: PMC4059092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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