Article

Automated optimisation of solubility and conformational stability of antibodies and proteins

2022-05-20

Abstract excerpt

Biologics, such as antibodies and enzymes, are crucial in research, biotechnology, diagnostics, and therapeutics. Often, biologics with suitable functionality are discovered, but their development is impeded by developability issues. Stability and solubility are key biophysical traits underpinning developability potential, as they determine aggregation, correlate with production yield and polyspecificity, and are...

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Literature Corpus work: da78fd04-0b84-5d15-bb1b-05f1a590a558
DOI: 10.1101/2022.05.20.492798

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