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Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patches

2024-03-12

Abstract excerpt

The formulation of high-concentration monoclonal antibody (mAb) solutions in low dose volumes for autoinjector devices poses challenges in manufacturability and patient administration due to elevated solution viscosity. In the current study, we present a systematic experimental framework for the computational screening of molecular descriptors to guide the design of mutants with modified viscosity profiles accompa...

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Literature Corpus work
67b11b12-5af0-5b1f-b3fa-d5f6ea0afff3
DOI
10.1101/2024.03.07.583917
Open publication

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Enhancing viscosity control in antibody formulations: A framework for the biophysical screening of mutations targeting solvent-accessible hydrophobic and electrostatic patchesDOI 10.1101/2024.03.07.583917
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