Article
Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.
PloS one - 1 Jan 2020
Apgar James R, Tam Amy S P, Sorm Rhady, Moesta Sybille, King Amy C, Yang Han, Kelleher Kerry, Murphy Denise, D'Antona Aaron M, Yan Guoying, Zhong Xiaotian, Rodriguez Linette, Ma Weijun, Ferguson Darren E, Carven Gregory J, Bennett Eric M, Lin Laura
Abstract excerpt
For an antibody to be a successful therapeutic many competing factors require optimization, including binding affinity, biophysical characteristics, and immunogenicity risk. Additional constraints may arise from the need to formulate antibodies at high concentrations (>150 mg/ml) to enable subcutaneous dosing with reasonable volume (ideally <1.0 mL). Unfortunately, antibodies at high concentrations may exhibit...
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