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Modeling the impact of amino acid substitution in a monoclonal antibody on cation exchange chromatography

19 Apr 2021

Abstract excerpt

A vital part of biopharmaceutical research is decision making around which lead candidate should be progressed in early-phase development. When multiple antibody candidates show similar biological activity, developability aspects are taken into account to ease the challenges of manufacturing the potential drug candidate. While current strategies for developability assessment mainly focus on drug product...

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PMID: 33871060
DOI: 10.1002/bit.27798

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