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Article

Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic <i>versus</i> electrostatic inter-molecular interactions

2 Jan 2015

Abstract excerpt

High viscosity of monoclonal antibody formulations at concentrations ≥100 mg/mL can impede their development as products suitable for subcutaneous delivery. The effects of hydrophobic and electrostatic intermolecular interactions on the solution behavior of MAB 1, which becomes unacceptably viscous at high concentrations, was studied by testing 5 single point mutants. The mutations were designed to reduce...

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PMID: 25559441
DOI: 10.4161/19420862.2014.985504

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