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Article

An "Fc-Silenced" IgG1 Format With Extended Half-Life Designed for Improved Stability.

Journal of pharmaceutical sciences - 1 Apr 2017

Borrok M Jack, Mody Neil, Lu Xiaojun, Kuhn Megan L, Wu Herren, Dall'Acqua William F, Tsui Ping

Abstract excerpt

Multiple mutation combinations in the IgG Fc have been characterized to tailor immune effector function or IgG serum persistence to fit desired biological outcomes for monoclonal antibody therapeutics. An unintended consequence of introducing mutations in the Fc (particularly the CH2 domain) can be a reduction in biophysical stability which can correlate with increased aggregation propensity, poor...

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Share to Protein Stability
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28057542
DOI: 10.1016/j.xphs.2016.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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