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Article

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin.

eLife - 6 Sept 2018

Phillips Angela M, Doud Michael B, Gonzalez Luna O, Butty Vincent L, Lin Yu-Shan, Bloom Jesse D, Shoulders Matthew D

Abstract excerpt

We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host's ER via a complex pathway. By integrating chemical methods to modulate ER proteostasis with deep mutational scanning to assess mutational tolerance, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30188321
DOI: 10.7554/eLife.38795
PMCID: PMC6172027

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