Article

Stability evolution as a major mechanism of human protein adaptation in response to viruses

2022-12-01

Abstract excerpt

Pathogens were a major driver of genetic adaptation during human evolution. Viruses in particular were a dominant driver of adaptation in the thousands of proteins that physically interact with viruses (VIPs for Virus-Interacting Proteins). This however poses a conundrum. The best understood cases of virus-driven adaptation in specialized immune antiviral factors or in host viral receptors are numerically vastly i...

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Literature Corpus work: e08725b8-dc90-514f-957d-c4d44c7ef6a8
DOI: 10.1101/2022.12.01.518739

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