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Influenza A viruses balance ER stress with host protein synthesis shutoff

3 Sept 2021

Abstract excerpt

Excessive production of viral glycoproteins during infections poses a tremendous stress potential on the endoplasmic reticulum (ER) protein folding machinery of the host cell. The host cell balances this by providing more ER resident chaperones and reducing translation. For viruses, this unfolded protein response (UPR) offers the potential to fold more glycoproteins. We postulated that viruses could have...

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PMID: 34479996
DOI: 10.1073/pnas.2024681118

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