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Article

Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin.

Journal of virology - 21 Apr 2026

Liu Binjian, Yu Hai, Yan Zhanfei, Zou Shuping, Guo Jinyue, Cai Shan, Hu Yingqin, Yang Yu, Yan Yulin, Liu Hao, Mei Kun, Li Zhili, Qin Limei, Li Yong, Huang Shujian, Wen Feng

Abstract excerpt

H9N2 avian influenza viruses (AIVs) remain a significant economic burden on poultry production and a persistent zoonotic threat. Hemagglutinin (HA), a surface glycoprotein mediating viral entry and pathogenesis, critically depends on thermostability for its function. Our previous study indicated that recent H9N2 AIVs have experienced a reduction in hemagglutination activity and exhibit low HA thermostability;...

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Hemagglutinin Glycoproteins, Influenza Virus
Hot Temperature
Influenza A Virus, H9N2 Subtype
Influenza in Birds
Mutagenesis, Site-Directed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Stability

Virus Internalization

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Identifiers

PMID: 41837643
DOI: 10.1128/jvi.00168-26
PMCID: PMC13098216

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