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Dynamin-2 mutations linked to neonatal-onset centronuclear myopathy impair exocytosis and endocytosis in adrenal chromaffin cells.

Journal of neurochemistry - 1 Sept 2024

Bayonés Lucas, Guerra-Fernández María José, Figueroa-Cares Cindel, Gallo Luciana I, Alfonso-Bueno Samuel, Caspe Octavio, Canal María Pilar, Báez-Matus Ximena, González-Jamett Arlek, Cárdenas Ana M, Marengo Fernando D

Abstract excerpt

Dynamins are large GTPases whose primary function is not only to catalyze membrane scission during endocytosis but also to modulate other cellular processes, such as actin polymerization and vesicle trafficking. Recently, we reported that centronuclear myopathy associated dynamin-2 mutations, p.A618T, and p.S619L, impair Ca2+-induced exocytosis of the glucose transporter GLUT4 containing vesicles in immortalized...

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Identifiers

PMID: 39126680
DOI: 10.1111/jnc.16194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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