Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

American journal of physiology. Cell physiology - 1 Jan 2015

Calvo-Gallardo Enrique, de Pascual Ricardo, Fernández-Morales José-Carlos, Arranz-Tagarro Juan-Alberto, Maroto Marcos, Nanclares Carmen, Gandía Luis, de Diego Antonio M G, Padín Juan-Fernando, García Antonio G

Abstract excerpt

Altered synaptic transmission with excess glutamate release has been implicated in the loss of motoneurons occurring in amyotrophic lateral sclerosis (ALS). Hyperexcitability or hypoexcitability of motoneurons from mice carrying the ALS mutation SOD1(G93A) (mSOD1) has also been reported. Here we have investigated the excitability, the ion currents, and the kinetics of the exocytotic fusion pore in chromaffin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catecholamines

Share to Chromaffin Cells

Share to Exocytosis

Share to Ion Transport

Share to Membrane Fusion

Share to Receptors, Nicotinic

Source

Identifiers

PMID: 25377090
DOI: 10.1152/ajpcell.00272.2014

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depressed excitability and ion currents linked to slow exocytotic fusion pore in chromaffin cells of the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.PMID 25377090Read ↗

Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Early excitability changes in lumbar motoneurons of transgenic SOD1G85R and SOD1G(93A-Low) mice.Semantic proximity Read ↗

Altered excitability and exocytosis in chromaffin cells from the R6/1 mouse model of Huntington's disease is linked to over-expression of mutated huntingtin.Semantic proximity Read ↗

The leaner P/Q-type calcium channel mutation renders cerebellar Purkinje neurons hyper-excitable and eliminates Ca2+-Na+ spike bursts.Semantic proximity Read ↗

The sodium leak channel NALCN is regulated by neuronal SNARE complex proteinsSemantic proximity Read ↗

Excitability properties of mouse motor axons in the mutant SOD1(G93A) model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Evidence from computer simulations for alterations in the membrane biophysical properties and dendritic processing of synaptic inputs in mutant superoxide dismutase-1 motoneurons.Semantic proximity Read ↗

Voltage-dependent sodium channels in spinal cord motor neurons display rapid recovery from fast inactivation in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons.Semantic proximity Read ↗

Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders.Semantic proximity Read ↗

Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental DisordersSemantic proximity Read ↗

Structure, diversity, and ionic permeability of neuronal and muscle acetylcholine receptors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.