The prognostic effects of somatic mutations in ER-positive breast cancer.

doi:10.1038/s41467-018-05914-x

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Article

The prognostic effects of somatic mutations in ER-positive breast cancer.

Nature communications - 4 Sept 2018

Griffith Obi L, Spies Nicholas C, Anurag Meenakshi, Griffith Malachi, Luo Jingqin, Tu Dongsheng, Yeo Belinda, Kunisaki Jason, Miller Christopher A, Krysiak Kilannin, Hundal Jasreet, Ainscough Benjamin J, Skidmore Zachary L, Campbell Katie, Kumar Runjun, Fronick Catrina, Cook Lisa, Snider Jacqueline E, Davies Sherri, Kavuri Shyam M, Chang Eric C, Magrini Vincent, Larson David E, Fulton Robert S, Liu Shuzhen, Leung Samuel, Voduc David, Bose Ron, Dowsett Mitch, Wilson Richard K, Nielsen Torsten O, Mardis Elaine R, Ellis Matthew J

Abstract excerpt

Here we report targeted sequencing of 83 genes using DNA from primary breast cancer samples from 625 postmenopausal (UBC-TAM series) and 328 premenopausal (MA12 trial) hormone receptor-positive (HR+) patients to determine interactions between somatic mutation and prognosis. Independent validation of prognostic interactions was achieved using data from the METABRIC study. Previously established associations...

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Identifiers

PMID: 30181556
DOI: 10.1038/s41467-018-05914-x
PMCID: PMC6123466

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