Article
Interplay between ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis.
Breast cancer research : BCR - 2 Oct 2023
Gerratana Lorenzo, Davis Andrew A, Velimirovic Marko, Clifton Katherine, Hensing Whitney L, Shah Ami N, Dai Charles S, Reduzzi Carolina, D'Amico Paolo, Wehbe Firas, Medford Arielle, Wander Seth A, Gradishar William J, Behdad Amir, Puglisi Fabio, Ma Cynthia X, Bardia Aditya, Cristofanilli Massimo
Abstract excerpt
BACKGROUND: although being central for the biology and druggability of hormone-receptor positive, HER2 negative metastatic breast cancer (MBC), ESR1 and PIK3CA mutations are simplistically dichotomized as mutated or wild type in current clinical practice. METHODS: The study analyzed a multi-institutional cohort comprising 703 patients with luminal-like MBC characterized for circulating tumor DNA through next...
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