Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint.

doi:10.1101/gad.317966.118

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Article

Increased chromosomal mobility after DNA damage is controlled by interactions between the recombination machinery and the checkpoint.

Genes & development - 1 Sept 2018

Smith Michael J, Bryant Eric E, Rothstein Rodney

Abstract excerpt

During homologous recombination, cells must coordinate repair, DNA damage checkpoint signaling, and movement of chromosomal loci to facilitate homology search. In Saccharomyces cerevisiae, increased movement of damaged loci (local mobility) and undamaged loci (global mobility) precedes homolog pairing in mitotic cells. How cells modulate chromosome mobility in response to DNA damage remains unclear. Here, we...

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Identifiers

PMID: 30181361
DOI: 10.1101/gad.317966.118
PMCID: PMC6120718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.