Article

The translocation activity of Rad54 reduces crossover outcomes during homologous recombination

2024-01-25

Abstract excerpt

Homologous recombination (HR) is a template-based DNA double-strand break repair pathway that requires the selection of an appropriate DNA template for repair during the homology search stage of HR. Failure to execute the homology search quickly and efficiently can result in complex intermediates that generate genomic rearrangements, a hallmark of human cancers. Rad54 is an ATP dependent DNA motor protein that fun...

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Literature Corpus work: e667747e-4741-5c04-ab7a-b8feb051f0ee
DOI: 10.1101/2024.01.25.577253

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