Article

Differential role for VPS4 isoforms in cytokinetic abscission confers a regulatory function for monomeric VPS4A and VTA1 in mammalian cells

2023-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the human AAA-ATPase VPS4 isoform, VPS4A, cause severe Neurodevelopmental defects and Congenital Dyserythropoietic Anemia (CDA). VPS4 is a crucial component of the ESCRT system, which drives membrane remodeling in numerous cellular processes, including receptor degradation, cell division, and neural pruning. Notably, while most organisms encode for a single VPS4 gene, human cells ha...

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Literature Corpus work: 8fa8e46e-d7d9-5727-963b-123bdfa58542
DOI: 10.1101/2023.09.11.557113

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