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Article

Performance of an image-only deep learning breast cancer risk model with the addition of a polygenic risk score.

British journal of cancer - 1 Jun 2026

Azam Shadi, Lamb Leslie R, Eliassen A Heather, King Tari A, Specht Michelle, Kraft Peter, Lindstrom Sara, Lehman Constance D, Tamimi Rulla M

Abstract excerpt

BACKGROUND: Mammograms contain imaging biomarkers that can predict future breast cancer risk using deep learning (DL) models. We evaluated whether adding a polygenic risk score (PRS) improves performance of the image-only DL breast cancer risk model Mirai. METHODS: This nested case-control study within the Nurses' Health Study 2 included 902 women (270 cases, 632 controls) who underwent bilateral 2D digital...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41942608
DOI: 10.1038/s41416-026-03415-z
PMCID: PMC13183889

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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