The contributions of breast density and common genetic variation to breast cancer risk.

doi:10.1093/jnci/dju397

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Article

The contributions of breast density and common genetic variation to breast cancer risk.

Journal of the National Cancer Institute - 1 May 2015

Vachon Celine M, Pankratz V Shane, Scott Christopher G, Haeberle Lothar, Ziv Elad, Jensen Matthew R, Brandt Kathleen R, Whaley Dana H, Olson Janet E, Heusinger Katharina, Hack Carolin C, Jud Sebastian M, Beckmann Matthias W, Schulz-Wendtland Ruediger, Tice Jeffrey A, Norman Aaron D, Cunningham Julie M, Purrington Kristen S, Easton Douglas F, Sellers Thomas A, Kerlikowske Karla, Fasching Peter A, Couch Fergus J

Abstract excerpt

We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting and Data System (BI-RADS) breast density were independent risk factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. We incorporated the PRS odds ratio (OR) into the Breast Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable risk...

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Identifiers

PMID: 25745020
DOI: 10.1093/jnci/dju397
PMCID: PMC4598340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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