Article

Mutations in the Ankyrin Repeat Domain of the Human TRPV4 Protein Aﬀect Binding of ATP: a Combined Molecular Dynamics and Network Analysis Study

2020-11-06

Abstract excerpt

Molecular dynamics (MD) simulations and residue interaction network analyses were carried out to investigate how some mutations on the human TRPV4 ankyrin repeating domain (ARD) change the ATP-binding strengths. Contact residue interaction networks (RINs) generated from the MD simulation trajectories are connected graphs with the ATP nodes having high importance. Besides four ATP-binding residues identiﬁed in earl...

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Literature Corpus work: 11a070e0-7636-5838-9a47-545110dc1443
DOI: 10.22541/au.160466112.22270946/v1

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