Article
Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1.
Stem cell research - 1 Nov 2016
Poon Anna, Schmid Benjamin, Pires Carlota, Nielsen Troels T, Hjermind Lena E, Nielsen Jørgen E, Holst Bjørn, Hyttel Poul, Freude Kristine K
Abstract excerpt
Mutations in the presenilin 1 (PSEN1) gene lead to the most aggressive form of familial Alzheimer's disease (AD). Human induced pluripotent stem cells (hiPSCs) derived from AD patients and subsequently differentiated can be used for disease modeling. We have previously generated a hiPSC line from a familial AD patient carrying a L150P point mutation in PSEN1. Here we used CRISPR/Cas9 gene editing to correct for...
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