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Article

Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.

PloS one - 1 Jan 2018

Skarp Sini, Kämäräinen Olli-Pekka, Wei Gong-Hong, Jakkula Eveliina, Kiviranta Ilkka, Kröger Heikki, Auvinen Juha, Lehenkari Petri, Ala-Kokko Leena, Männikkö Minna

Abstract excerpt

INTRODUCTION: Osteoarthritis (OA) is the most common degenerative joint disease and one of the major causes of disability worldwide. It is a multifactorial disorder with a significant genetic component. The heritability of OA has been estimated to be 60% for hip OA and 39% for knee OA. Genetic factors behind OA are still largely unknown. Studying families with strong history of OA, facilitates examining the...

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PMID: 30157244
DOI: 10.1371/journal.pone.0203313
PMCID: PMC6114922

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OLIG3

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