Article
A variant in MCF2L is associated with osteoarthritis.
American journal of human genetics - 9 Sept 2011
Day-Williams Aaron G, Southam Lorraine, Panoutsopoulou Kalliope, Rayner Nigel W, Esko Tonu, Estrada Karol, Helgadottir Hafdis T, Hofman Albert, Ingvarsson Throvaldur, Jonsson Helgi, Keis Aime, Kerkhof Hanneke J M, Thorleifsson Gudmar, Arden Nigel K, Carr Andrew, Chapman Kay, Deloukas Panos, Loughlin John, McCaskie Andrew, Ollier William E R, Ralston Stuart H, Spector Timothy D, Wallis Gillian A, Wilkinson J Mark, Aslam Nadim, Birell Fraser, Carluke Ian, Joseph John, Rai Ashok, Reed Mike, Walker Kirsten, Doherty Sally A, Jonsdottir Ingileif, Maciewicz Rose A, Muir Kenneth R, Metspalu Andres, Rivadeneira Fernando, Stefansson Kari, Styrkarsdottir Unnur, Uitterlinden Andre G, van Meurs Joyce B J, Zhang Weiya, Valdes Ana M, Doherty Michael, Zeggini Eleftheria
Abstract excerpt
Osteoarthritis (OA) is a prevalent, heritable degenerative joint disease with a substantial public health impact. We used a 1000-Genomes-Project-based imputation in a genome-wide association scan for osteoarthritis (3177 OA cases and 4894 controls) to detect a previously unidentified risk locus. We discovered a small disease-associated set of variants on chromosome 13. Through large-scale replication, we...
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