Article
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
Annals of the rheumatic diseases - 1 Dec 2014
Evangelou Evangelos, Kerkhof Hanneke J, Styrkarsdottir Unnur, Ntzani Evangelia E, Bos Steffan D, Esko Tonu, Evans Daniel S, Metrustry Sarah, Panoutsopoulou Kalliope, Ramos Yolande F M, Thorleifsson Gudmar, Tsilidis Konstantinos K, Arden Nigel, Aslam Nadim, Bellamy Nicholas, Birrell Fraser, Blanco Francisco J, Carr Andrew, Chapman Kay, Day-Williams Aaron G, Deloukas Panos, Doherty Michael, Engström Gunnar, Helgadottir Hafdis T, Hofman Albert, Ingvarsson Thorvaldur, Jonsson Helgi, Keis Aime, Keurentjes J Christiaan, Kloppenburg Margreet, Lind Penelope A, McCaskie Andrew, Martin Nicholas G, Milani Lili, Montgomery Grant W, Nelissen Rob G H H, Nevitt Michael C, Nilsson Peter M, Ollier William Er, Parimi Neeta, Rai Ashok, Ralston Stuart H, Reed Mike R, Riancho Jose A, Rivadeneira Fernando, Rodriguez-Fontenla Cristina, Southam Lorraine, Thorsteinsdottir Unnur, Tsezou Aspasia, Wallis Gillian A, Wilkinson J Mark, Gonzalez Antonio, Lane Nancy E, Lohmander L Stefan, Loughlin John, Metspalu Andres, Uitterlinden Andre G, Jonsdottir Ingileif, Stefansson Kari, Slagboom P Eline, Zeggini Eleftheria, Meulenbelt Ingrid, Ioannidis John Pa, Spector Tim D, van Meurs Joyce B J, Valdes Ana M
Abstract excerpt
OBJECTIVES: Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects. METHODS: We performed a two-stage meta-analysis on more than 78,000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres were used for 'in...
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