Article
Identification of novel genetic variations affecting osteoarthritis patients.
BMC medical genetics - 10 Oct 2016
Gari Mamdooh Abdullah, AlKaff Mohammed, Alsehli Haneen S, Dallol Ashraf, Gari Abdullah, Abu-Elmagd Muhammad, Kadam Roaa, Abuzinadah Mohammed F, Gari Mazin, Abuzenadah Adel M, Gauthaman Kalamegam, Alkhatabi Heba, Abbas Mohammed M
Abstract excerpt
BACKGROUND: Osteoarthritis (OA) is a progressive joint disease characterized by gradual degradation of extracellular matrix (ECM) components in the cartilage and bone. The ECM of cartilage is a highly specified structure that is mainly composed of type II collagen and provides tensile strength to the tissue via aggrecan and proteoglycans. However, changes in the ECM composition and structure can lead to loss of...
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