Article
Next-generation sequencing approaches for the study of genome and epigenome toxicity induced by sulfur mustard.
Archives of toxicology - 1 Dec 2018
Panahi Yunes, Fattahi Amir, Zarei Fatemeh, Ghasemzadeh Navid, Mohammadpoor Abbas, Abroon Sina, Nojadeh Jafar Nouri, Khojastefard Mehran, Akbarzadeh Abolfazl, Ghasemnejad Tohid
Abstract excerpt
Sulfur mustard (SM) is an extensive nucleophilic and alkylating agent that targets different tissues. The genotoxic property of SM is the most threatening effect, because it is associated with detrimental inflammations and susceptibility to several kinds of cancer. Moreover, SM causes a wide variety of adverse effects on DNA which result in accumulation of DNA adducts, multiple mutations, aneuploidies, and...
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