Genome-wide mapping of genomic DNA damage: methods and implications.

doi:10.1007/s00018-021-03923-6

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Article

Genome-wide mapping of genomic DNA damage: methods and implications.

Cellular and molecular life sciences : CMLS - 1 Nov 2021

Amente Stefano, Scala Giovanni, Majello Barbara, Azmoun Somaiyeh, Tempest Helen G, Premi Sanjay, Cooke Marcus S

Abstract excerpt

Exposures from the external and internal environments lead to the modification of genomic DNA, which is implicated in the cause of numerous diseases, including cancer, cardiovascular, pulmonary and neurodegenerative diseases, together with ageing. However, the precise mechanism(s) linking the presence of damage, to impact upon cellular function and pathogenesis, is far from clear. Genomic location of specific...

Topics

Animals
Chromosome Mapping
DNA
DNA Damage
Genome
Genome-Wide Association Study
Genomics
Humans
Mutation
Neoplasms

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Identifiers

PMID: 34463773
DOI: 10.1007/s00018-021-03923-6
PMCID: PMC8558167

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