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Article

m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.

Nature cell biology - 1 Sept 2018

Liu Jun, Eckert Mark A, Harada Bryan T, Liu Song-Mei, Lu Zhike, Yu Kangkang, Tienda Samantha M, Chryplewicz Agnieszka, Zhu Allen C, Yang Ying, Huang Jing-Tao, Chen Shao-Min, Xu Zhi-Gao, Leng Xiao-Hua, Yu Xue-Chen, Cao Jie, Zhang Zezhou, Liu Jianzhao, Lengyel Ernst, He Chuan

Abstract excerpt

N6-methyladenosine (m6A) messenger RNA methylation is a gene regulatory mechanism affecting cell differentiation and proliferation in development and cancer. To study the roles of m6A mRNA methylation in cell proliferation and tumorigenicity, we investigated human endometrial cancer in which a hotspot R298P mutation is present in a key component of the methyltransferase complex (METTL14). We found that about 70%...

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Share to Adenosine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30154548
DOI: 10.1038/s41556-018-0174-4
PMCID: PMC6245953

Genes

METTL14
METTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

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Research trail→

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m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.PMID 30154548Read ↗

A cancer-associated METTL14 mutation induces aberrant m6A modification, affecting tumor growth.Semantic proximity Read ↗

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