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Article

PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells.

Cancer research - 15 Aug 2014

Wandzioch Ewa, Pusey Michelle, Werda Amy, Bail Sophie, Bhaskar Aishwarya, Nestor Mariya, Yang Jing-Jing, Rice Lyndi M

Abstract excerpt

Protein phosphatase 2A (PP2A) negatively regulates tumorigenic signaling pathways, in part, by supporting the function of tumor suppressors like p53. The PP2A methylesterase PME-1 limits the activity of PP2A by demethylating its catalytic subunit. Here, we report the finding that PME-1 overexpression correlates with increased cell proliferation and invasive phenotypes in endometrial adenocarcinoma cells, where it...

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Identifiers

PMID: 24928782
DOI: 10.1158/0008-5472.CAN-13-3130

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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